Exactly what is divalproex-sodium?

Divalproex sodium is a prescription medicine. It is available in 3 kinds: dental delayed-release tablets, oral extended-release tablet computers, as well as oral spray capsules.

Divalproex sodium dental tablet is offered as the brand-name medicines Depakote (delayed launch) and also Depakote ER (extensive release). It’s additionally offered in common types. Common drugs typically set you back much less compared to the brand-name version. In many cases, they could not be offered in every toughness or type as the brand-name drug.

Divalproex sodium might be utilized as component of a combination treatment. That means you need to take it with various other drugs.

Why it’s used?

Divalproex sodium dental tablet is used alone or with other drugs to:

Deal with seizures. These include:

  • intricate partial seizures that occur on their own or in organization with various other sorts of seizures.
  • straightforward as well as complicated lack seizures.
  • numerous seizure kinds that consist of absence seizures.
  • Treat the manic stage of bipolar illness. A manic episode is an amount of time where your state of mind is exceptionally strong. This could consist of a raised or an inflamed mood.
  • Stop migraine headache headaches. There is no proof that it works to deal with a migraine frustration when you currently have one.

How it works?

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Divalproex sodium oral tablet comes from a class of drugs called anti-epileptics. A course of drugs is a group of medicines that run in a comparable way. These medications are usually used to treat comparable problems.

This medicine works by raising mind concentrations of a specific chemical, GABA, which lowers the excitability of your nervous system. This aids to deal with seizures and manic episodes as well as avoid migraine headaches.

Divalproex sodium negative effects

Divalproex sodium oral tablet can create drowsiness and dizziness. Don’t drive a lorry, use machinery, or do other activities that require performance up until you recognize just how this medication impacts you.

This medication could also cause opposite side results.

Divalproex sodium might interact with other drugs

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Divalproex sodium dental tablet can connect with various other medicines, vitamins, or herbs you may be taking. A communication is when a compound alters the way a medication works. This could be damaging or prevent the drug from functioning well.

To assist avoid interactions, your physician needs to take care of all of your medicines meticulously. Make sure to tell your physician about all medicines, vitamins, or natural herbs you’re taking. To find out how this medication may communicate with something else you’re taking, talk with your medical professional or pharmacologist.

Instances of drugs that can cause interactions with divalproex sodium are here.

Anesthetic medication
Taking propofol with divalproex sodium can increase the levels of propofol in your body. If you need to take these medications with each other, your doctor will likely decrease your dosage of propofol.

Anti-seizure medication
Taking felbamate with divalproex sodium could boost the level of divalproex sodium in your body and raise your risk of adverse effects. If you take felbamate with divalproex sodium, your medical professional may adjust your dose of divalproex sodium.

Anti-seizure as well as migraine headache avoidance medication
Taking topiramate with divalproex sodium might boost your threat of high ammonia degrees in your blood, or reduced body temperature (hypothermia). If you’re taking these medicines with each other, your doctor should monitor your blood ammonia levels and also temperature level.

Pain killers
Taking pain killers with divalproex sodium might boost the level of divalproex sodium in your body as well as boost your danger of adverse effects. If you take aspirin with divalproex sodium, your physician could adjust your dose of divalproex sodium.

Blood thinner drug
Taking warfarin with divalproex sodium might enhance the levels of warfarin in your body. Your doctor may check your INR if you need to take divalproex sodium along with warfarin.

Carbapenem prescription antibiotics
Taking these medicines with divalproex salt might decrease the degree of divalproex sodium in your body. This means that it could not function too to treat your condition. If you need to take one of these antibiotics while taking divalproex salt, your medical professional will certainly monitor your blood degrees very closely. Examples of these antibiotics include:

  • ertapenem
  • imipenem
  • meropenem
  • HIV medication
  • Taking zidovudine with divalproex salt might enhance the degrees of zidovudine in your body. Your physician may monitor you more very closely for negative effects.

Hormonal contraception that contains estrogen
Taking some birth control drugs with divalproex salt can decrease the amount of divalproex sodium in your body, making it less effective. If you need to make use of hormone contraception, such as the tablet, your doctor will likely keep track of the amount of divalproex salt in your body.

State of mind condition and also seizure medications
Taking certain mood problem and seizure drugs with divalproex salt might increase the degrees of these medicines in your body. Your medical professional might readjust your dose of these drugs or monitor you more very closely for adverse effects. Examples of these medications include:

Taking various other state of mind problem and seizure drugs with divalproex sodium could decrease the level of divalproex sodium in your body. This indicates that it could not work also to treat your problem. Your physician could adjust your dosage of divalproex sodium. Instances of these drugs consist of:

Tuberculosis medication
Taking rifampin with divalproex salt might decrease the degree of divalproex salt in your body. This implies that it could not function as well to treat your problem. If you take these medicines with each other, your physician may readjust your dosage of divalproex salt.

Divalproex sodium warnings

This medication includes numerous warnings.

Allergic reaction warning
This medicine can trigger a serious allergy (hypersensitivity). Symptoms may include:

trouble ingesting or breathing
swelling of your throat, tongue, eyes, or lips
hives or skin breakout
sores in your mouth
blistering as well as peeling off of your skin
swelling of your lymph nodes
If you create these signs, call 911 or most likely to the nearby emergency room.

Do not take this medication once again if you have actually ever before had an allergy to it. Taking it again can be deadly (cause fatality).

Alcohol interaction warning
Divalproex sodium could trigger sleepiness and lightheadedness. Do not drink alcohol while taking this medication due to the fact that it can increase your threats of reduced reflexes, bad judgment, as well as drowsiness.

Cautions for people with certain health problems
For individuals with liver condition: If you have a background of liver illness, you could have a higher risk of liver failure within the first six months of therapy with this medication. Your medical professional will certainly monitor you for indicators of liver damage.

For individuals with mitochondrial illness: If you have Alpers-Huttenlocher syndrome or have a household history of this metabolic disorder, you may have a greater threat of liver failing when taking divalproex sodium.

For people with urea cycle problems: If you have a urea cycle problem, you should not take this medicine. It could increase your danger of hyperammonemia (high ammonia degrees in your blood). This problem could be fatal.

Cautions for various other groups
For pregnant females: This medicine might cause severe damage to your maternity. If you take this drug while pregnant, your baby is at threat of serious abnormality. These consist of abnormality that impact the mind, spinal cord, heart, head, arms, legs, as well as the opening where urine appears. These issues can take place in the first month of pregnancy, before you recognize you’re pregnant.

If you become pregnant while taking this medicine, talk to your doctor concerning signing up with the North American Antiepileptic Medication Maternity Windows Registry. The function of this computer system registry is to collect information about the security of drugs used to deal with seizures during pregnancy.

If you conceive while taking this drug, call your medical professional today.

For therapy of seizures as well as manic episodes of bipolar disorder in expecting females: Divalproex sodium is a group D maternity medication. That implies two things:
Studies show a risk of damaging results to the unborn child when the mother takes the medication.
The advantages of taking the medication while pregnant might exceed the possible threats in certain instances.
Inform your doctor if you’re expecting or plan to become expectant. Divalproex sodium ought to just be utilized while pregnant for women with seizures or manic episodes if the possible benefit validates the potential risk.

For prevention of migraine headaches in expecting females: Divalproex sodium is a category X pregnancy medication. Group X drugs ought to never be made use of while pregnant for women with migraine frustrations.
For ladies who are nursing: This medicine travels through breast milk as well as could create severe effects in a breastfeeding youngster. You as well as your doctor could need to determine if you’ll take divalproex sodium or breastfeed.

For seniors: Your body processes divalproex sodium extra slowly. You might also experience more of a sedative impact from this medication. Severe drowsiness might create you to consume or drink much less compared to you usually would. Inform your medical professional if this occurs.

Your doctor will certainly monitor just how much you eat and drink and examine you for indicators of dehydration, sleepiness, wooziness, and other side results. They might quit offering you this medicine if you aren’t eating or drinking sufficient or if you have severe sleepiness.

For children: Youngsters below 2 years old have actually a boosted threat of liver damage while taking this medicine, specifically if they also take other medicines to treat seizures.


Divalproex sodium dental tablet is used for long-term medication therapy. For manic episodes of bipolar affective disorder, your physician will certainly choose whether this is a temporary or lasting medicine therapy.

This medication has serious dangers if you do not take it as prescribed.

If you don’t take it whatsoever or miss out on doses: If you don’t take this medicine on a regular basis, you miss dosages, or you stop taking it unexpectedly, there could be major dangers. The problem that you’re trying to deal with may not get better. You might likewise experience even more adverse effects from this medication if you take it on and also off.

If you stop taking it suddenly: If you’re taking this medicine to deal with seizures, quiting it suddenly can trigger a seizure that won’t stop (condition epilepticus).

If you take way too much: Taking too much of this medicine could cause harmful effects, such as:

severe fatigue
uneven heart price as well as rhythm
high degrees of sodium in your blood
deep coma
If you think you have actually taken too much of this medication, call your doctor or local toxin control center. If your signs and symptoms are severe, call 911 or go to the local emergency room right now.

What to do if you miss out on a dose: If you neglect to take your dosage of this drug, take it as quickly as you bear in mind. If it’s simply a few hrs up until the time for your next dose, wait and take just one dose back then.

Never ever aim to capture up by taking 2 doses simultaneously. This might trigger dangerous adverse effects.

The best ways to inform if the medication is working: For therapy of seizures: Your seizure control ought to improve.

For therapy of manic episodes of bipolar illness: You should see a reduction in symptoms brought on by the manic phase of bipolar affective disorder. Your mood ought to be well managed.

For avoidance of migraine headache headaches: You should have fewer migraines.

Important considerations for taking divalproex

Maintain these considerations in mind if your medical professional prescribes divalproex sodium for you.

If this medication distress your tummy, take it with food.
Do not squash or eat the tablet computers.
Shop delayed release tablets listed below 86 ° F( 30 ° C). Shop extended-release tablet computers at a temperature between 59 ° F as well as 86 ° F( 15 ° C and 30 ° C). Don’t save this medication in damp or wet locations, such as restrooms.
A prescription for this drug is refillable. You need to not need a brand-new prescription for this medicine to be re-filled. Your doctor will certainly compose the number of refills accredited on your prescription.

When taking a trip with your medication:

Constantly lug your medicine with you. When flying, never ever placed it into an examined bag. Maintain it in your carry-on bag.
Don’t stress about airport terminal X-ray machines. They cannot damage your drug.
You could have to reveal flight terminal staff the pharmacy label for your medicine. Always lug the initial prescription-labeled container with you.
Do not put this medicine in your car’s glove compartment or leave it in the automobile. Be sure to stay clear of doing this when the weather is really warm or very cool.
Professional surveillance
Prior to starting and also throughout treatment with this drug, your physician could inspect your:

medication plasma levels (your doctor might examine the degrees of the drug in your body if you’re having adverse effects or to decide if you need a dose adjustment).
liver feature.
body temperature level.
ammonia level.
Your medical professional could additionally monitor you for indications of pancreatitis or self-destructive thoughts or actions.

Are there any alternatives?

There are various other medicines available to treat your condition. Some might be far better fit for you compared to others. Talk to your doctor regarding other medication choices that could help you.

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